Many-membered heterocyclic compounds. XII. Formation of 15-pentadecanolide from 15-bromopentadecanoic acid was written by Stoll, M.. And the article was included in Helvetica Chimica Acta in 1947.Product Details of 56523-59-2 This article mentions the following:
Because the method of Kerschbaum (C.A. 21, 2118) for the lactonization of higher ω-Br fatty acids, using their Ag salts, gives very low yields, this reaction is studied in detail, using other salts and various solvents and concentrations The results are given in a table. The best results are obtained when the K 15-bromopentadecanoate is lactonized in a specially designed apparatus in MeCOEt, giving 85% 15-pentadecanolide (I), b0.1 122°, m. 32-6°. Using the method of Hunsdiecker, et al. (French 839,188), with and without K2CO3, yields of 82.8% I are obtained in both cases. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Product Details of 56523-59-2).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 56523-59-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary