Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents was written by Saczewski, Franciszek;Stencel, Agnieszka;Bienczak, Andrzej M.;Langowska, Karolina A.;Michaelis, Martin;Werel, Wladyslaw;Halasa, Rafal;Reszka, Przemyslaw;Bednarski, Patrick J.. And the article was included in European Journal of Medicinal Chemistry in 2008.Related Products of 18791-79-2 This article mentions the following:
Eighteen new 2,6-disubstituted acrylonitriles, e. g. I, and two new (benzimidazol-1-yl)-acetamide derivatives were prepared and screened for antibacterial and cytotoxic activities on 12 human cancer cell lines. Based on the lead structure 2-(benzimidazol-2-yl)-3-(5-nitrothiophen-2-yl) acrylonitrile it was found that placement of Me groups at the 5,6 positions of the benzimidazole ring lead to a 3-fold increase in overall cytotoxic activity. Replacing the nitrothiophene for pyridine reduced cytotoxic activity as did replacing the nitro group for a methoxy group. Cytotoxic activity was only slightly reduced when the benzimidazole ring was replaced by a imidazo[4,5-b]pyridine or a benzthiazole ring but replacement by benzoxazole led to a substantial decrease in activity. Moving the acrylonitrile group from position 2 to position 1 of the benzimidazole ring also resulted in moderately active compounds Benzimidazol-1-ylacetamides showed only modest activity. The structure-activity relationships found in the cytotoxicity studies are mirrored in the results of the antibacterial experiments In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Related Products of 18791-79-2).
5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 18791-79-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary