Direct Construction of Fused Indoles by Gold-Catalyzed Cascade Cyclization of Conjugated Diynes was written by Naoe, Saori;Saito, Tatsuo;Uchiyama, Masanobu;Oishi, Shinya;Fujii, Nobutaka;Ohno, Hiroaki. And the article was included in Organic Letters in 2015.Name: Methyl 3-bromo-4-fluorobenzoate This article mentions the following:
A gold-catalyzed cascade cyclization of aniline derivatives bearing a conjugated diyne moiety was developed. Following the 5-endo-dig indole formation, subsequent 7-endo-dig cyclization predominated over 6-exo-dig cyclization to give the indole fused with a seven-membered ring in good yields. E.g., in presence of IPrAuCl and AgOTf in DCE at 50 °C, cascade cyclization of diyne (I) gave 86% II and III (88:12). In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6Name: Methyl 3-bromo-4-fluorobenzoate).
Methyl 3-bromo-4-fluorobenzoate (cas: 82702-31-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Name: Methyl 3-bromo-4-fluorobenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary