Heterocyclic systems containing bridgehead nitrogen atom: Part XXXIX. Reaction of 2-mercapto-4-bromo-6-methylbenzimidazole with chloroacetic acid and 1,2-dibromoethane was written by Jain, K. K.;Pujari, H. K.. And the article was included in Indian Journal of Chemistry in 1981.Quality Control of 2-Bromo-4-methyl-6-nitroaniline This article mentions the following:
The thiazolobenzimidazoles I (X = O, S) were synthesized from 2-mercapto-4-bromo-6-methylbenzimidazole (II), which was prepared by the reaction of 3-bromo-5-methyl-1,2-diaminobenzene with CS2; II on condensation with ClCH2CO2H followed by cyclization with Ac2O gave I (X = O) and not the linear isomer. Reaction of II with 1,2-dibromoethane gave I (X = H2) and not the linear isomer. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Quality Control of 2-Bromo-4-methyl-6-nitroaniline).
2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Quality Control of 2-Bromo-4-methyl-6-nitroaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary