Month: January 2023

Synthesis of ω-hydroxy quaternary ammonium bolaform surfactants was written by Davey, Tim W.;Hayman, Alan R.. And the article was included in Australian Journal of Chemistry in 1998.Application of 56523-59-2 This article mentions the following:

Several members of a novel class of ω-substituted asym. bolaform surfactants were synthesized to investigate their surfactant and biol. properties. The ω-hydroxy trialkylammonium and pyridinium surfactants have significant antimicrobial and antifungal activity relative to their conventional analogs. For conventional quaternary ammonium alkyl surfactants, increasing the hydrocarbon chain length causes a decrease in the surfactant monomer solubility and a corresponding decrease in the biol. activity. No such trend is observed for the ω-hydroxy quaternary ammonium bromide series. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Application of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Self-Assembly of Liquid Crystalline Triphenylenedicarboxythioimides was written by Psutka, Katie M.;Le Drew, Joshua;Taing, Hi;Eichhorn, S. Holger;Maly, Kenneth E.. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 859299-66-4 This article mentions the following:

We report the synthesis and properties of a series of novel triphenylenedicarboxyimides and thioimides (R = decyl) to probe the effect of thionation on the formation of columnar mesophases. These materials display broad columnar mesophases and high clearing points and self-associate in solution to form dimers. Overall, thionation improved the self-assembly in solution and led to a stabilization of the columnar mesophase. Furthermore, increasing the thionation of these materials led to a lowering of the LUMO energy level and a narrowing of the HOMO-LUMO gap. In the experiment, the researchers used many compounds, for example, Dimethyl 4,5-dibromophthalate (cas: 859299-66-4Recommanded Product: 859299-66-4).

Dimethyl 4,5-dibromophthalate (cas: 859299-66-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 859299-66-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In vitro and in vivo comparative study of a novel ⁶⁸Ga-labeled PSMA-targeted inhibitor and ⁶⁸Ga-PSMA-11 was written by Chen, Huanyu;Cai, Ping;Feng, Yue;Sun, Zhanliang;Wang, Yinwen;Chen, Yue;Zhang, Wei;Liu, Nan;Zhou, Zhijun. And the article was included in Scientific Reports in 2021.Electric Literature of C13H14BrNO2 This article mentions the following:

⁶⁸Ga-radiolabeled small mols. that specifically target prostate-specific membrane antigen (PSMA) have been extensively investigated, and some of these tracers have been used in the diagnosis of prostate cancer via 68Ga-positron emission tomog. (⁶⁸Ga-PET). Nevertheless, current ⁶⁸Ga-labeled radiotracers show only fair detection rates for metastatic prostate cancer lesions, especially those with lower levels of prostate specific antigen (PSA), which often occurs in the biochem. recurrence of prostate cancer. The goal of this study was to design and synthesize a new PSMA-targeted radiotracer, ⁶⁸Ga-SC691, with high affinity for prostate cancer cells and excellent pharmacokinetics. To this end, structural optimization was carried out on the bifunctional group, target motif, and linker while the high affinity targeting scaffold remained. To explore its potential in the clinic, a comparative study was further performed in vitro and in vivo between ⁶⁸Ga-SC691 and ⁶⁸Ga-PSMA-11, a clin. approved tracer for PSMA-pos. prostate cancer. SC691 was radiolabeled to provide ⁶⁸Ga-SC691 in 99% radiolabeling yield under mild conditions. High uptake and a high internalization ratio into LNCaP cells were observed in in vitro studies. In vivo studies showed that ⁶⁸Ga-SC691 had favorable biodistribution properties and could specifically accumulate on PSMA-pos. LNCaP xenografts visualized by micro-PET/CT. This radiotracer showed excellent PET imaging quality and comparable, if not higher, uptake in LNCaP xenografts than ⁶⁸Ga-PSMA-11. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Electric Literature of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Aromatic sulfonyl fluorides. III was written by Steinkopf, Wilhelm;Hubner, Rolf. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1934.COA of Formula: C6H4BrFO2S This article mentions the following:

An 86% yield of p-EtC₆H₄SO₂F (I), b. 238-9°, b₁₄ 124.5°, is obtained from 50 g. EtPh and 200 g. FSO₃H, together with a small amount of (p-EtC₆H₄)₂SO₂, m. 98°, but no trace of a disulfonyl fluoride. The nitration of I gives 4,3-Et(O₂N)C₆H₃SO₂F, b₁₅ 179°. Adding 25 g. MeI and 5 g. Mg in 200 cc. of ether to 16 g. of I in 100 cc. of ether gives 7.3 g. of (p-EtC₆H₄SO₂)₂CH₂, m. 131°, soluble in alc., ether and hot KOH, not soluble in H₂O. Adding 16 g. BrPh and 2.8 g. Mg in 150 cc. ether to 10 g. of I in 150 cc. ether gives 4.2 g. of p-EtC₆H₄SO₂Ph, m. 91.5-2.0°. Adding 25 g. MeI and 5 g. Mg in 100 cc. of ether to 10.5 g. of 2,4-Me₂C₆H₃SO₂F (II) gives 7.75 g. of (2,4-Me₂-C₆H₃SO₂)₂CH₂, m. 155.5-6.0°. Adding 20 g. BrPh and 6 g. Mg in 300 cc. ether to 13 g. of II gives 5.7 g. of 2,4-Me₂C₆H₃SO₂Ph, m. 87°. Adding 15 g. of 1,3-dimethyl-2,4-benzenedisulfonyl fluoride (III) to 25 g. MeI and 5.4 g. Mg in 150 cc. ether gives a mixture of C₁₇H₁₈O₆F₂S₄, m. 135°, C₁₇H₁₈O₆F₂S₄, m. 272°, and 1,3,2,4-Me₂ (MeO₂S)₂-C₆H₂, m. 187°. Adding 16 g. BrPh and 2.6 g. Mg in 100 cc, ether to 12 g. of III in 250 cc. ether gives 7 g. of 1,3,2,4-Me₂(PhO₂S)₂C₆H₂, m. 232-3°. Adding 14.3 g. of 1,5-dichloropentane and 5 g. Mg in ether slowly to 42 g. of II in ether gives 11 g. of 2,4-Me₂C₆H₃SO₂(CH₂)₅-O₂SC₆H₃Me₂-2,4, m. 98°. A Sandmeyer reaction gives (from the amino derivative) 60% of m-ClC₆H₄SO₂F, b₂₂ 90°, or m-BrC₆H₄SO₂F, b₂₃ 122°, the nitration of which gives 3,4-Cl(O₂N)C₆H₃SO₂F, m. 85° (81% yield), or 3,4-Br-(O₂N)C₆H₃SO₂F, m. 104° (84% yield), resp. The compounds described are new. In the experiment, the researchers used many compounds, for example, 3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9COA of Formula: C6H4BrFO2S).

3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.COA of Formula: C6H4BrFO2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design was written by Dong, Xiaowu;Zhan, Wenhu;Zhao, Mengting;Che, Jinxin;Dai, Xiaoyang;Wu, Yizhe;Xu, Lei;Zhou, Yubo;Zhao, Yanmei;Tian, Tian;Cheng, Gang;Jin, Zegao;Li, Jia;Shao, Yanfei;He, Qiaojun;Yang, Bo;Weng, Qinjie;Hu, Yongzhou. And the article was included in Journal of Medicinal Chemistry in 2019.Safety of Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate This article mentions the following:

A series of 3,4-disubstituted piperidine derivatives were obtained based on a conformational restriction strategy and a lead compound, A12, that exhibited potent in vitro and in vivo antitumor efficacies; however, obvious safety issues limited its further development. Thus, systematic exploration of the structure-activity relationship of compound A12, involving the Ph group, hinge-linkage, and piperidine moiety, led to the discovery of the superior 3,4,6-trisubstituted piperidine derivative E22. E22 showed increased potency in Akt1 and cancer cell inhibition, remarkably reduced human ether-a-go-go-related gene blockage, and significantly improved safety profiles. Compound E22 also exhibited good kinase selectivity, had a good pharmacokinetic profile, and displayed very potent in vivo antitumor efficacy, with over 90% tumor growth inhibition in the SKOV3 xenograft model. Further mechanistic studies were conducted to demonstrate that compound E22 could significantly inhibit the phosphorylation of proteins downstream of Akt kinase in cells and tumor tissue from the xenograft model. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3Safety of Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate).

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fast atom bombardment and laser desorption mass spectrometry for determination of alkyltriphenylphosphonium salts was written by McCrery, D. A.;Peake, D. A.;Gross, Michael L.. And the article was included in Analytical Chemistry in 1985.Computed Properties of C23H26BrP This article mentions the following:

Mass spectra of alkyltriphenylphosphonium halides were obtained by using fast atom bombardment (FAB) coupled with tandem mass spectrometry (MS/MS) and laser desorption (LD) with Fourier-transform mass spectrometry (FTMS). In addition, collisionally activated dissociation (CAD) spectra of laser-desorbed phosphonium ions were obtained. The 2 methods of ionization are equally useful in determining mol. weight of the phosphonium ions. However, high-energy collisional activation is needed to obtain unambiguous structural confirmation of the alkyl group. In addition, ion abundance ratios provide information about the internal energy of the phosphonium ions produced by LD and FAB. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Computed Properties of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Computed Properties of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Enhancing anion conduction stability of quaternized poly(phenylene) oxide-based anion exchange membranes with ionic liquids modified carbon nanomaterials was written by Wang, Ning;Zuo, Tingting;Liu, Ke;Jia, Jing;Song, Di;Wei, Xiaoqing;Hu, Shu;Che, Quantong. And the article was included in International Journal of Energy Research in 2022.Recommanded Product: 128-08-5 This article mentions the following:

The anion exchange membrane (AEM) with high and stable conductivity is important to the com. application of anion exchange membrane fuel cell. The AEM based on the polymer of quaternized poly(phenylene) oxide (QPPO) with enhanced anion conduction stability has been constructed through the introduction of the ionic liquid (IL) of 1-aminopropyl-3-methylimidazolium bromide (APMIMBr)-modified carbon nanomaterials, such as carbon nanotubes oxide (OCNT) and graphene oxide (GO) nanosheets. The IL-OCNT and IL-GO composites prevented hydroxyl groups from attacking the polymer of QPPO. Thus, QPPO/x(IL-OCNT) and QPPO/x(IL-GO) series membranes possessed enhanced hydroxide conductivity stability in alk. solution Specifically, QPPO/5%(IL-OCNT) and QPPO/5%(IL-GO) membranes exhibited the hydroxide conductivities of 23.0 and 28.5 mS/cm at 80°C. Notably, the hydroxide conductivities could reach 16.3 and 30.2 mS/cm while the prepared membranes were immersed in 2 M KOH solution for 1848 h. Furthermore, the stable hydroxide conductivity was derived from the fine dimension stability and mech. property. The tensile stress values were, resp., 19.4 and 19.8 MPa even if the membranes were immersed in alk. solution In the prepared QPPO/x(IL-OCNT) and QPPO/x(IL-GO) membranes, In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Divergent Access to Seven/Five-Membered Rings Based on [1,6]-Hydride Shift/Cyclization Process was written by Hoshino, Daiki;Mori, Keiji. And the article was included in Organic Letters in 2021.Recommanded Product: 61150-57-0 This article mentions the following:

A divergent access to seven/five-membered rings based on a [1,6]-hydride shift/cyclization process from benzylidenemalonate with an o-alkoxymethyl group was achieved. Whereas Yb(OTf)₃ afforded benzoxepines I [R = Me, Ph, 4-MeC₆H₄, 4-ClC₆H₄; R¹ = H, Me; R² = H, Me, MeO, F; R³ = H, Me, MeO, F; R²R³ = CH=CH-CH=CH] selectively and indanes II [R⁴ = H, Me; R⁵ = H, MeO; R⁶ = H, Me, MeO, F] were the main products when Sc(OTf)₃ was employed. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Recommanded Product: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of monosubstituted [1.1.1]propellanes was written by Bothe, Harald;Schlueter, Arnulf Dieter. And the article was included in Chemische Berichte in 1991.Electric Literature of C7H15BrO This article mentions the following:

Wittig reaction of (ClCH₂)₂CO with RCH:PPh₃ [R = Me(CH₂)_n, MeO(CH₂)_m; n = 4, 6, 10; m = 3, 5] in Et₂O-hexane gave 32-48% RCH:C(CH₂Cl)₂, which underwent cycloaddition with :CBr₂ to give 20-57% bis(chloromethyl)dibromocyclopropanes I. Treating I with MeLi in Et₂O gave 21-64% title propellanes II, which polymerized spontaneously at room temperature in the absence of inhibitors. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Electric Literature of C7H15BrO).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Electric Literature of C7H15BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Supramolecular glycopolymers with thermo-responsive self-assembly and lectin binding was written by Cakir, Nese;Hizal, Gurkan;Becer, C. Remzi. And the article was included in Polymer Chemistry in 2015.Application of 53784-83-1 This article mentions the following:

Incorporating monomers into sequence-defined synthetic macromols. endows them to mimic nature which results in key residues being anchored in the mol. recognition pattern. Developing controlled carbohydrate sequences has critical importance in understanding the multivalent binding motifs of oligosaccharide and sequence-controlled glycopolymers to various lectins. Here, we describe the development of thermo-responsive copolymer scaffolds bearing adamantane groups that enable the formation of an inclusion complex with mono and hepta mannosylated-cyclodextrin mols. through host-guest interaction. We have demonstrated the synthesis of a triblock copolymer via RAFT polymerization, the complexation of the adamantane containing a thermoresponsive copolymer and α-D-mannose-CD, as well as their interactions with Con A. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Application of 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary