Month: January 2023

Preparation of a conjugated tautomer of 1,14:7,8-Diethenotetrapyrido[2,1-6-de:2′,1′-6′-gh:2”,1”,6”-k1:2”’,1”’,6”’-na][1,3,5,8,10,12,]hexaazacyclotetradecine and its metal derivatives was written by Ogawa, Shojiro;Yamaguchi, Tomonobu;Gotoh, Nobuyuki. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1974.Electric Literature of C12H7BrN2 This article mentions the following:

The title tetradecine (I) with high thermal stability, was prepared by 2,9-diamino-1,10-phenanthroline thermolysis or condensation with 2,9-dihalo-1,10-phenanthroline. The structure of I was a conjugated system related to porphin and phthalocyanine. The metal complexes II-IV were prepared In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Electric Literature of C12H7BrN2).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C12H7BrN2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens was written by Wu, Yongqi;Wang, Bin;Lu, Haijia;Zhao, Hongyi;Yang, Beibei;Li, Li;Lu, Yu;Zhang, Dongfeng;Sun, Ning;Huang, Haihong. And the article was included in Journal of Medicinal Chemistry in 2021.Related Products of 4133-72-6 This article mentions the following:

A series of conformationally constrained novel benzo[1,3]oxazinyloxazolidinones were designed, synthesized, and evaluated on their activities against Mycobacterium tuberculosis, Gram-pos. bacteria, and Gram-neg. bacteria. The studies identified a new compound 20aa that displayed good to excellent antibacterial and antitubercular profiles against drug-resistant TB strains (MIC = 0.48-0.82μg/mL), MRSA (MIC = 0.25-0.5μg/mL), MRSE (MIC = 1μg/mL), VISA (MIC = 0.25μg/mL), and VRE (MIC = 0.25μg/mL) and some linezolid-resistant strains (MIC 1-2μg/mL). Compound 20aa was demonstrated as a promising candidate through ADME/T evaluation including microsomal stability, cytotoxicity, and inhibition of hERG and monoamine oxidase. Notably, 20aa showed excellent mouse PK profile with high plasma exposure (AUC_{0-âˆ?/sub> = 78 669 h·ng/mL), high peak plasma concentration (Cmax = 10 253 ng/mL), appropriate half-life of 3.76 h, and superior oral bioavailability (128%). The present study not only successfully provides a novel benzo[1,3]oxazinyloxazolidinone scaffold with superior druggability but also lays a good foundation for new antibacterial drug development. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-4-fluoro-2-hydroxybenzoate (cas: 4133-72-6Related Products of 4133-72-6).}

Methyl 5-bromo-4-fluoro-2-hydroxybenzoate (cas: 4133-72-6) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Related Products of 4133-72-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Visible-Light-Enabled Decarboxylative Mono- and Difluoromethylation of Cinnamic Acids under Metal-Free Conditions was written by Tang, Wei-Ke;Feng, Yi-Si;Xu, Zhuo-Wei;Cheng, Zhi-Fei;Xu, Jun;Dai, Jian-Jun;Xu, Hua-Jian. And the article was included in Organic Letters in 2017.Electric Literature of C9H6BrFO2 This article mentions the following:

Several new mono- and difluoromethylation reactions of cinnamic acids using an Eosin Y catalytic system are reported. An efficient alkene fluoromethylation of α,β-unsaturated carboxylic acids, e.g., I, II, and III, was accomplished under ambient temperature and metal-free conditions, with a wide range of functional group tolerance. A mechanism that involves a radical process is proposed for this reaction. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1Electric Literature of C9H6BrFO2).

3-Bromo-4-fluorocinnamic acid (cas: 160434-49-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C9H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 2,3′-spirobi[indolin]-2-ones enabled by a tandem nucleophilic benzylation/C(sp²)-N cross-coupling reaction sequence was written by Cui, Baodong;Shan, Jing;Yuan, Changlun;Han, Wenyong;Wan, Nanwei;Chen, Yongzheng. And the article was included in Organic & Biomolecular Chemistry in 2017.Product Details of 61150-57-0 This article mentions the following:

An efficient complementary strategy for the construction of spiro[pyrrolidin-3,2′-oxindole] derivatives has been described. With the sequential nucleophilic benzylation and copper-catalyzed intramol. C(sp²)-N cross-coupling reaction of 3-aminooxindoles with 2-bromobenzyl bromides, a wide range of 2,3′-spirobi[indolin]-2-ones, e.g., I (X-rays single crystal structure shown), were smoothly obtained in moderate to good yields. A plausible catalytic cycle for this tandem reaction process was proposed based on the control experiments This study represents a new perspective for the synthesis of structurally diverse spirocyclic oxindoles by employing 3-aminooxindole substrates. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Product Details of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Separation of lanthanides and actinides using magnetic silica particles bearing covalently attached tetra-CMPO-calix[4]arenes was written by Boehmer, Volker;Dozol, Jean-Francois;Gruettner, Cordula;Liger, Karine;Matthews, Susan E.;Rudershausen, Sandra;Saadioui, Mohamed;Wang, Pingshan. And the article was included in Organic & Biomolecular Chemistry in 2004.Electric Literature of C13H14BrNO2 This article mentions the following:

Calix[4]arene tetraethers in the cone conformation bearing four -NH-CO-CH₂-P(O)Ph₂ (= CMPO) residues on their wide rim and one, two or four ω-amino alkyl residues of various lengths at the narrow rim were synthesized. Reaction with dichlorotriazinyl (DCT) functionalized magnetic particles led to complete coverage of the available surface by covalently linked CMPO-calix[4]arenes in all cases. Magnetically assisted removal of Eu(3+) and Am(3+) from acidic solutions was distinctly more efficient with these particles in comparison to analogous particles bearing the same amount of analogous single-chain CMPO-functions. The best result, an increase of the extraction efficiency by a factor of 140-160, was obtained for attachment via two Pr spacers. The selectivity Am/Eu was in the range of 1.9-2.8. No decrease of the extraction ability was observed, when the particles were repeatedly used, after simple back extraction with water. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Electric Literature of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

TEMPO-Promoted Mono- and Bisimidation of Tertiary Anilines: Synthesis of Symmetric and Unsymmetric N-Mannich Bases was written by Xu, Xiu Juan;Amuti, Adila;Hu, Wen Jing;Adelibieke, Qiaerbati;Wusiman, Abudureheman. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

A TEMPO-promoted method was developed for the synthesis of sym. bis-N-Mannich bases R¹CH₂N(Ar)(R²) [R¹ = H, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, etc.; R² = 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, 3-oxo-3a,4,5,6,7,7a-hexahydro-1H-isoindol-2-yl; Ar = Ph, 4-MeC₆H₄, 1-naphthyl, etc.] via sequential activation of two α,α’-amino C(sp³)-H bonds of N,N-dimethylanilines under mild conditions. This methodol. was further extended for monoimidation of α-amino-functionalized methylanilines to give unsym. N-Mannich bases in good to high yields. Several control experiments were performed, and the coupling reaction outcomes indicated that the oxoammonium (TEMPO⁺) species is involved in the reaction. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Post-polymerization modification of a hydroxy monolith precursor. Part II. Epoxy biphenyl modified poly (hydroxyethyl methacrylate-co- pentaerythritol triacrylate) monolithic capillary columns for reversed-phase capillary electrochromatography based on π-π and hydrophobic interactions was written by Khadka, Shantipriya;Rassi, Ziad El. And the article was included in Electrophoresis in 2016.Product Details of 615-55-4 This article mentions the following:

In this second part of the series of investigations involving the post polymerization modification of a hydroxy monolith (OHM) capillary column, the surface hydroxyl groups were reacted with epoxy biphenyl thus yielding the so-called Biphenyl OHM capillary column. The modification involved the epoxy ring opening of the 2-biphenylyl glycidyl ether catalyzed by BF₃ and its subsequent reaction with the hydroxyl groups on the OHM precursor. The Biphenyl OHM capillary column thus obtained exhibited the typical reversed phase behavior by primarily hydrophobic interactions vis-a-vis the homologous series of alkyl benzenes and in addition by π-π interactions towards nitroalkane homologous series via their π-electron rich nitro groups. This dual retention mechanism was very distinctly observed with a set of polyaromatic hydrocarbon (PAH) solutes in the sense that the k values of the PAH solutes were comparable to those obtained on a more non polar stationary phase, namely the Epoxy OHM C-16 reported in the preceding article. Other aromatic solutes showed the dual retention mechanism on the Biphenyl OHM capillary including phenols, anilines derivatives and phenoxy acid herbicides. The Biphenyl OHM capillary exhibited good reproducibility from run-to-run, day-to-day and column-to-column. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Product Details of 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer was written by Chen, Jinying;Sang, Zitai;Jiang, Youjun;Yang, Chao;He, Linhong. And the article was included in Chemical Biology & Drug Design in 2019.Related Products of 76437-44-0 This article mentions the following:

Fifty-eight quinazoline-based compounds were designed and synthesized based on the structural optimizations from the lead compound 23bb in an attempt to search for more potent dual HDAC1 and HDAC6 inhibitors. Among them, 32c (HDAC1, IC₅₀ = 31.10 ± 0.37 nM; HDAC6, IC₅₀ = 16.15 ± 0.62 nM) and 32d (HDAC1, IC₅₀ = 37.00 ± 0.24 nM; HDAC6, IC₅₀ = 35.00 ± 0.71 nM) were not only identified as potent dual-acting HDAC1 and HDAC6 inhibitors with over 10-fold selectivity to the other HDACs, but also displayed activities in tubulin acetylation and histone H₃ acetylation induction. Importantly, both of them displayed strong antiproliferative activities against various tumor cell lines in vitro with IC₅₀ values <40 nM, especially for hematol. tumors cells (U266 and RPMI8226, IC₅₀ < 1 nM), which were even better than 23bb and SAHA. Furthermore, 32c showed a significant tumor growth inhibition (antitumor rate = 63.98%, p < 0.05) in the resistant MCF-7/ADR xenograft model without any obvious body weight changes and abnormal behaviors. The authors’ findings validate that 32c is a potent dual inhibitor of HDAC1/6 that can be an efficacious treatment for breast cancer with Adriamycin resistance. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Related Products of 76437-44-0).

1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 76437-44-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A New TBAF Complex, Highly Stable, Facile and Selective Source for Nucleophilic Fluorination: Applications in Batch and Flow Chemistry was written by Said, Madhukar S.;Khonde, Nilesh S.;Thorat, Meghana N.;Atapalkar, Ranjit S.;Kulkarni, Amol A.;Gajbhiye, Jayant;Dastager, Syed G.. And the article was included in Asian Journal of Organic Chemistry in 2020.Product Details of 14425-64-0 This article mentions the following:

Natural polysaccharides supported tetrabutylammonium fluoride (TBAF) complexes were prepared and found to be highly stable and selective fluoride source for well-reowned nucleophilic (S_N2-type) substitution reaction for the first time. Bacterial cellulose, plant cellulose, pectin, and starch derived TBAF complexes were synthesized, characterized (using SEM, TEM, and NMR techniques) and studied for their stability and reactivity. Heterogeneous bacterial cellulose-TBAF complex (N-Bu₄(Bac-cell-OH)F) was found to be highly stable and non-hygroscopic among all complexes, which gave high yields of fluorinated products in multi-gram scale in shorter reaction time. The primarily developed batch protocol was extended to solid-solid continuous flow reaction using an inhouse built screw reactor, which furnished products in a few seconds of residence time (tR=20-25 s) and excellent yields. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Product Details of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors was written by Rupiani, Sebastiano;Buonfiglio, Rosa;Manerba, Marcella;Di Ianni, Lorenza;Vettraino, Marina;Giacomini, Elisa;Masetti, Matteo;Falchi, Federico;Di Stefano, Giuseppina;Roberti, Marinella;Recanatini, Maurizio. And the article was included in European Journal of Medicinal Chemistry in 2015.SDS of cas: 881676-32-0 This article mentions the following:

Glycolysis is drastically increased in tumors and it is the main route to energy production with a minor use of oxidative phosphorylation. Among the key enzymes in the glycolytic process, LDH is emerging as one of the most interesting targets for the development of new inhibitors. In this context, in the present work, we carried out a virtual screening procedure followed by chem. modifications of the identified structures according to a “hit-to-lead” process. The effects of the new mols. were preliminary probed against purified human LDH-A. The compounds active at low micromolar level were addnl. characterized for their activity on some cellular metabolic processes by using Raji human cell line. Within the series, 1 was considered the best candidate, and a more detailed characterization of its biol. properties was performed. In Raji cells exposed to compound 1 we evidenced the occurrence of effects usually observed in cancer cells after LDH-A inhibition: reduced lactate production and NAD/NADH ratio, apoptosis. The flow cytometry anal. of treated cells also showed cell cycle changes compatible with effects exerted at the glycolytic level. Finally, in agreement with the data obtained with other inhibitors or by silencing LDH-A expression, compound 1 was found to increase Raji cells response to some commonly used chemotherapeutic agents. Taken together, all these finding are in support of the LDH-A inhibiting activity of compound 1. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0SDS of cas: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.SDS of cas: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary