Synthesis of 2-methyl-5-amino-4-oxo-3-sulfonyl esters as precursors of pseudodipeptides was written by Severi, D.;Ettouati, L.;Paris, J.. And the article was included in Letters in Peptide Science in 2002.Related Products of 2178-24-7 This article mentions the following:
The synthesis of 2-methyl-5-amino-4-oxo-3-sulfonyl esters Boc-NHCHRCOCH(SO2Ph)CHMeCO2Et (Boc = tert-butoxycarbonyl, R = H or Me), potential precursors of XaaΨ[COCH2]Ala, XaaΨ[E-CH:CH]Ala and XaaΨ[CH2CH2]Ala pseudodipeptides, has been investigated by alkylation of glycine- and alanine-derived β-keto sulfones with Et 2-bromo- or 2-(triflyloxy)propionate under basic conditions. Yields of 2-methyl-5-amino-4-oxo-3-sulfonyl esters are low but starting β-keto sulfones are recovered in good yield. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Related Products of 2178-24-7).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 2178-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary