Zhan, Wenhu et al. published their research in European Journal of Medicinal Chemistry in 2016 | CAS: 1196-90-3

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 1196-90-3

Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors was written by Zhan, Wenhu;Xu, Lei;Dong, Xiaowu;Dong, Jun;Yi, Xiao;Ma, Xiaodong;Qiu, Ni;Li, Jia;Yang, Bo;Zhou, Yubo;Hu, Yongzhou. And the article was included in European Journal of Medicinal Chemistry in 2016.Recommanded Product: 1196-90-3 This article mentions the following:

A series of novel pyrazolylfuran carboxamides I (24a–d; X = S, R2 = R3 = H; R1, R4: a, H, 4-F; b, Cl, 4-F; c, Br, 4-F; d, H, 3,4-Cl2; 25a–e, X = O, R3 = H, R1, R2, R4: a, Cl, H, 4-F; b, Br, H, 4-F; c, Br, H, 3,4-Cl2; d, Cl, Cl, 4-F; e, Cl, Cl, 3,4-Cl2; 27a–c, X = NMe, R1, R2, R3, R4: a, Br, H, H, 3,4-Cl2; b, Br, Br, H, 3,4-Cl2; c, Cl, Cl, Cl, 3,4-Cl2) and II (26a–c; R1, R2, R4: a, H, Br, 3,4-Cl2; b, Cl, Br, 3,4-Cl2; c, Br, Br, 3,4-Cl2) were designed, synthesized and biol. evaluated for their Akt1 inhibitory activities, as well as anti-proliferative efficacies against HCT116 and OVCAR-8 cell lines. Most compounds exhibited moderate to excellent Akt1 inhibitory activities, together with favorable cytotoxicities. Further kinase selectivity assay of the most promising compound 25e illustrated that it was also potent against the structurally related AGC kinases, including Akt2, Akt3, ROCK1 and PKA, but was specific over kinases from other subfamilies. In addition, the Western blot anal. indicated that 25e could significantly suppress the phosphorylation level of Akt substrate GSK3β in PC-3 cell. Moreover, 25e demonstrated a concentration-dependent inhibition of phosphorylation of PRAS40 in LNCaP cell, with IC50 value of 30.4 nM. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3Recommanded Product: 1196-90-3).

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 1196-90-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary