TEMPO-Promoted Mono- and Bisimidation of Tertiary Anilines: Synthesis of Symmetric and Unsymmetric N-Mannich Bases was written by Xu, Xiu Juan;Amuti, Adila;Hu, Wen Jing;Adelibieke, Qiaerbati;Wusiman, Abudureheman. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 128-08-5 This article mentions the following:
A TEMPO-promoted method was developed for the synthesis of sym. bis-N-Mannich bases R1CH2N(Ar)(R2) [R1 = H, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, etc.; R2 = 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, 3-oxo-3a,4,5,6,7,7a-hexahydro-1H-isoindol-2-yl; Ar = Ph, 4-MeC6H4, 1-naphthyl, etc.] via sequential activation of two α,α’-amino C(sp3)-H bonds of N,N-dimethylanilines under mild conditions. This methodol. was further extended for monoimidation of α-amino-functionalized methylanilines to give unsym. N-Mannich bases in good to high yields. Several control experiments were performed, and the coupling reaction outcomes indicated that the oxoammonium (TEMPO+) species is involved in the reaction. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).
1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 128-08-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary