Effect of Benzylic Methyl Groups on Kinetic Basicity of Amine Ligand in o-Boron Substituted N,N-Dimethylbenzylamines was written by Toyota, Shinji;Asakura, Mitsuhiro;Futawaka, Tadahiro;Oki, Michinori. And the article was included in Bulletin of the Chemical Society of Japan in 1999.Related Products of 173026-23-8 This article mentions the following:
Rates of the dissociation of the intramol. B-N coordination bond in two series of phenylborane derivatives, the boronate and diethylborane complexes, with -CHMeNMe2 or -CMe2NMe2 group at the o-position were determined by the NMR lineshape anal. or saturation transfer method. The new organoboron compounds were synthesized from the corresponding organolithium compounds with appropriate boron reagents. Comparison of the kinetic data with those of the -CH2NMe2 compounds reveals that the barrier height to the dissociation, namely the kinetic basicity of the amine ligand, is increased as the mol. possesses more Me groups at the benzylic position for both of the series of boron compounds The x-ray structure of one of the boronate complexes and the NMR titration measurements of model amines indicate that the basicity of the amine ligand is not affected much by the Me substitution in the coordinated form. Therefore, the substituent effect on the kinetic basicity is mainly ascribed to the destabilization of the transition state by the geminal di-Me groups rather than to any inductive or steric effects at the initial state, especially for the -CMe2NMe2 compounds In the experiment, the researchers used many compounds, for example, 2-(2-Bromophenyl)propan-2-amine (cas: 173026-23-8Related Products of 173026-23-8).
2-(2-Bromophenyl)propan-2-amine (cas: 173026-23-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Related Products of 173026-23-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary