Palladium catalyzed synthesis of quinazolino[1,4]benzodiazepine alkaloids and analogs was written by Sorra, Kumaraswamy;Mukkanti, K.;Pusuluri, Srinivas. And the article was included in Tetrahedron in 2012.Product Details of 653-92-9 This article mentions the following:
A concise synthesis of enantiopure quinazolino[1,4]benzodiazepine was accomplished by palladium-catalyzed N-arylation of amidines with o-bromobenzoates followed by intra mol. cyclization. The strategy was successfully applied to the total synthesis of pyrrolo quinazolino[1,4]benzodiazepine alkaloids such as circumdatin H, J and other analogs. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Product Details of 653-92-9).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Product Details of 653-92-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary