Copper(I)-Catalyzed Enyne Oxidation/Cyclopropanation: Divergent and Enantioselective Synthesis of Cyclopropanes was written by Shen, Wen-Bo;Tang, Xiang-Ting;Zhang, Ting-Ting;Lv, Dong-Can;Zhao, Dan;Su, Tong-Fu;Meng, Lei. And the article was included in Organic Letters in 2021.Safety of 2-Bromo-4-(trifluoromethyl)benzaldehyde This article mentions the following:
An efficient copper(I)-catalyzed enyne R2CCN(R1)CH2C(R3)=CHR4 (R1 = Ms, Ts, SO2Ph, Bs; R2 = Ph, 3-bromophenyl, thiophen-3-yl, etc.; R3 = H, Me; R4 = H, Me, Ph, 4-chlorophenyl, etc.) and 2-(CH2=CH)-R5C6H3C(O)CCR6 (R5 = H, Me, 5-F, etc.; R6 = Ph, 4-fluorophenyl, 4-methoxyphenyl) oxidation/cyclopropanation for the modular synthesis of cyclopropane derivatives I, II and III is described, which represents the first non-noble metal-catalyzed enynes oxidation/cyclopropanation by the in situ generated α-oxo copper carbenes. This protocol allows the assembly of valuable cyclopropane-γ-lactams I and II in generally good to excellent yields with excellent diastereoselectivity. More significantly, the enantioselective version of enyne oxidation/cyclopropanation has been disclosed with chiral copper catalysts. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Safety of 2-Bromo-4-(trifluoromethyl)benzaldehyde).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of 2-Bromo-4-(trifluoromethyl)benzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary