Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44 was written by Shearman, James W.;Myers, Rebecca M.;Beale, Thomas M.;Brenton, James D.;Ley, Steven V.. And the article was included in Tetrahedron Letters in 2010.Electric Literature of C8H6Br2O2 This article mentions the following:
The total syntheses of the bromotyrosine-derived natural products ianthelline (I), 5-bromoverongamine (II) and JBIR-44 (III) are described and their cytotoxic activity in a cervical cancer (HeLa) cell line and human umbilical vein endothelial cells (HUVECs) are reported. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Electric Literature of C8H6Br2O2).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C8H6Br2O2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary