New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents was written by Schmitt, Florian;Gold, Madeleine;Rothemund, Matthias;Andronache, Ion;Biersack, Bernhard;Schobert, Rainer;Mueller, Thomas. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 108940-96-1 This article mentions the following:
Aminonaphthopyrancarbonitriles I [R = 3-O2NC6H4, 3,5-F2C6H3, 3-NCC6H4, 3,5-Cl2-4-MeOC6H2, 3,5-Br2-4-MeOC6H2, 3,5-I2-4-MeOC6H2, 4-NCC6H4, 3-F5SC6H4, 4-F5SC6H4, 4-MeSC6H4, 4-(PhCH2O)-3-MeOC6H3, 4-Cl-3-FC6H3, 3-BrC6H4, 2-ClC6H4] were prepared as analogs of the antiproliferative naphthopyran LY290181 for potential use as antitumor agents. I were prepared by cyclocondensation of malonitrile, 1-naphthol or 4-chloro-1-naphthol, and aryl aldehydes RCHO [R = 3-O2NC6H4, 3,5-F2C6H3, 3-NCC6H4, 3,5-Cl2-4-MeOC6H2, 3,5-Br2-4-MeOC6H2, 3,5-I2-4-MeOC6H2, 4-NCC6H4, 3-F5SC6H4, 4-F5SC6H4, 4-MeSC6H4, 4-(PhCH2O)-3-MeOC6H3, 4-Cl-3-FC6H3, 3-BrC6H4, 2-ClC6H4]. The antitumor activities of I were determined in human cancer cells; the antiangiogenic, tubulin polymerization-inhibiting, and apoptosis-inducing activities of selected I were determined The highest antitumor activities were found for I substituted with aryl groups possessing small meta substituents. I led to G2/M arrest due to interruption of the microtubule dynamics and induced apoptosis. I also disrupted the vasculature of chorioallantoic membranes in fertilized chicken eggs and in xenograft tumors in mice. I (R = H; R1 = 3,5-F2C6H3) inhibited the growth of resistant xenograft tumors in mice. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Recommanded Product: 108940-96-1).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 108940-96-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary