Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus was written by Perlmutter, Jessamyn I.;Forbes, Lauren T.;Krysan, Damian J.;Ebsworth-Mojica, Katherine;Colquhoun, Jennifer M.;Wang, Jenna L.;Dunman, Paul M.;Flaherty, Daniel P.. And the article was included in Journal of Medicinal Chemistry in 2014.HPLC of Formula: 14425-64-0 This article mentions the following:
Staphylococcus aureus is a rapidly growing health threat in the U.S., with resistance to several commonly prescribed treatments. A high-throughput screen identified the antihistamine terfenadine to possess, previously unreported, antimicrobial activity against S. aureus and other Gram-pos. bacteria. In an effort to repurpose this drug, structure-activity relationship studies yielded 84 terfenadine-based analogs with several modifications providing increased activity vs. S. aureus and other bacterial pathogens, including Mycobacterium tuberculosis. Mechanism of action studies revealed these compounds to exert their antibacterial effects, at least in part, through inhibition of the bacterial type II topoisomerases. This scaffold suffers from hERG liabilities which were not remedied through this round of optimization; however, given the overall improvement in activity of the set, terfenadine-based analogs provide a novel structural class of antimicrobial compounds with potential for further characterization as part of the continuing process to meet the current need for new antibiotics. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0HPLC of Formula: 14425-64-0).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 14425-64-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary