Discovery of Small-Molecule Sulfonamide Fluorescent Probes for GPR120 was written by Liu, Pan;Ma, Siyue;Yan, Chongzheng;Qin, Xiaojun;Zhao, Pei;Li, Qi;Cui, Yuanyuan;Li, Minyong;Du, Lupei. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2019.Computed Properties of C13H14BrNO2 This article mentions the following:
GPR120 is a novel target for the treatment of metabolic disease and type 2 diabetes. The small-mol. fluorescent probe could help us locate GPR120 visually and guide in-depth study of GPR120. In this study, we synthesized six nonacidic sulfonamide fluorescent probes and tested their optical and biol. properties. Compared to previous probes for GPR120, these probes, with sulfonamide structure, have high selectivity on GPR120. We used these probes to establish a BRET binding assay system to screen agonists and antagonists of GPR120. It is expected that these novel fluorescent probes may become useful tools in studying pharmacol. and physiol. of GPR120. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Computed Properties of C13H14BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary