Stereoselective synthesis and fungicidal activities of (E)-α-(methoxyimino)-benzeneacetate derivatives containing 1,3,4-oxadiazole ring was written by Li, Yan;Liu, Jie;Zhang, Hongquan;Yang, Xiangping;Liu, Zhaojie. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Safety of Ethyl 4-bromo-2-fluorobenzoate This article mentions the following:
Fifteen novel (E)-α-(methoxyimino)benzeneacetate derivatives, the analogs of strobilurins, which contain two pharmacophoric substructures of (E)-Me methoxyiminoacetate moiety and 1,3,4-oxadiazole ring were stereoselectively synthesized. It was first found that the coupling reaction could give stereoselectively the key intermediate (E)- and (Z)-Me 2-(hydroxyimino)-2-o-tolylacetate with a ratio of 14:1. The preliminary bioassays indicated that all the compounds I (R = H, 4-MeO, 2,3-Cl2, 2-I, etc.) showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola and Bipolaris mayclis, and all of the tested compounds had more potent fungicidal activities against R. solani than Kresoxim-Me. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2Safety of Ethyl 4-bromo-2-fluorobenzoate).
Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of Ethyl 4-bromo-2-fluorobenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary