Synthesis of 2,3′-spirobi[indolin]-2-ones enabled by a tandem nucleophilic benzylation/C(sp2)-N cross-coupling reaction sequence was written by Cui, Baodong;Shan, Jing;Yuan, Changlun;Han, Wenyong;Wan, Nanwei;Chen, Yongzheng. And the article was included in Organic & Biomolecular Chemistry in 2017.Product Details of 61150-57-0 This article mentions the following:
An efficient complementary strategy for the construction of spiro[pyrrolidin-3,2′-oxindole] derivatives has been described. With the sequential nucleophilic benzylation and copper-catalyzed intramol. C(sp2)-N cross-coupling reaction of 3-aminooxindoles with 2-bromobenzyl bromides, a wide range of 2,3′-spirobi[indolin]-2-ones, e.g., I (X-rays single crystal structure shown), were smoothly obtained in moderate to good yields. A plausible catalytic cycle for this tandem reaction process was proposed based on the control experiments This study represents a new perspective for the synthesis of structurally diverse spirocyclic oxindoles by employing 3-aminooxindole substrates. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Product Details of 61150-57-0).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 61150-57-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary