Synthesis and biological evaluation of novel T-type calcium channel blockers was written by Choi, Ja Youn;Seo, Han Na;Lee, Min Joo;Park, Seong Jun;Park, Sung Jun;Jeon, Ji Young;Kang, Joo Hi;Pae, Ae Nim;Rhim, Hyewhon;Lee, Jae Yeol. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: N-(5-Bromopentyl)phthalimide This article mentions the following:
3,4-Dihydroquinazoline analogs, e.g., I, substituted by N-methyl-N-(5-pyrrolidinopentyl)amine at the 2-position were synthesized and their blocking effects were evaluated for T- and N-type calcium channels. I, compared to mibefradil (IC50 = 1.34 ± 0.49 μM), was about 5-fold potent (IC50 = 0.26 ± 0.01 μM) for T-type calcium channel (α1G) blocking and its selectivity of T/N-type was also improved (7.5 vs. 1.4 of mibefradil). In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: N-(5-Bromopentyl)phthalimide).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: N-(5-Bromopentyl)phthalimide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary