Structure-based search for new inhibitors of cholinesterases was written by Bajda, Marek;Wieckowska, Anna;Hebda, Michalina;Guzior, Natalia;Sotriffer, Christoph A.;Malawska, Barbara. And the article was included in International Journal of Molecular Sciences in 2013.Related Products of 954-81-4 This article mentions the following:
Cholinesterases are important biol. targets responsible for regulation of cholinergic transmission, and their inhibitors were used for the treatment of Alzheimer’s disease. To design new cholinesterase inhibitors, of different structure-based design strategies was followed, including the modification of compounds from a previously developed library and a fragment-based design approach. This led to the selection of heterodimeric structures as potential inhibitors. Synthesis and biol. evaluation of selected candidates confirmed that the designed compounds were acetylcholinesterase inhibitors with IC50 values in the mid-nanomolar to low micromolar range, and some of them were also butyrylcholinesterase inhibitors. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 954-81-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary