[Multicomponent Synthesis of 4-Aminophthalazin-1(2H)-ones by Palladium-Catalyzed Isocyanide Insertion was written by Vlaar, Tjoestil;Mampuys, Pieter;Helliwell, Madeleine;Maes, Bert U. W.;Orru, Romano V. A.;Ruijter, Eelco. And the article was included in Journal of Organic Chemistry in 2013.Related Products of 653-92-9 This article mentions the following:
4-Aminophthalazin-1(2H)-ones (APOs) are underexplored heterocyclic compounds with promising and diverse biol. activities. The classical synthesis of these compounds is tedious and does not allow the regioselective introduction of substituents. Here, we present our full studies on the Pd-catalyzed cross-coupling of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion allowing straightforward access to diversely substituted APOs. E.g., in presence of Pd(OAc)2 and Xantphos in DMSO, reaction of benzoate ester (I), tert-Bu isocyanide, and hydrazine hydrate gave 89% 4-aminophthalazin-1(2H)-one derivative (II). We illustrate the advantages of this method compared to other approaches and describe solutions for the limitations we encountered. In addition, we have developed efficient diversifications of this heterocyclic scaffold that allow access to more diverse APOs as well as novel heterocyclic scaffolds. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Related Products of 653-92-9).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 653-92-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary