Reactions of organic anions. 114. Specific ortho orientation in the vicarious substitution of hydrogen in aromatic nitro compounds with carbanion of chloromethylphenyl sulfone was written by Makosza, M.;Glinka, T.;Kinowski, A.. And the article was included in Tetrahedron in 1984.SDS of cas: 76437-44-0 This article mentions the following:
Vicarious nucleophilic substitution of hydrogen atoms in nitroarenes with chloromethyl Ph sulfone proceeds selectively ortho to the nitro group when carried out in Me3COK/THF base/solvent system. In the majority of 3-substituted nitrobenzene derivatives substitution occurs at the most hindered position 2. These conditions offer an efficient method of synthesis of 2,6 and 2,3-disubstituted nitrobenzene derivatives In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0SDS of cas: 76437-44-0).
1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 76437-44-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary