Syntheses of 3-furyl, 3-thienyl and 3-selenienyl propenoic acids and esters. A route to substituted thienothiophenes and selenolothiophenes was written by Capron, Bernard;Paulmier, Claude;Pastour, Paul. And the article was included in Bulletin de la Societe Chimique de France in 1975.Safety of 5-Bromothiophene-3-carbaldehyde This article mentions the following:
3-(Furyl, thienyl, or selenienyl)propenoic acids were prepared by modified Wittig reaction of the heterocyclic aldehydes and were cyclized with SOCl2 to give condensed thiophenes. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Safety of 5-Bromothiophene-3-carbaldehyde).
5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of 5-Bromothiophene-3-carbaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary