Asymmetric Iodonio-[3,3]-Sigmatropic Rearrangement to Access Chiral α-Aryl Carbonyl Compounds was written by Tian, Junsong;Luo, Fan;Zhang, Qifeng;Liang, Yuchen;Li, Dongyang;Zhan, Yaling;Kong, Lichun;Wang, Zhi-Xiang;Peng, Bo. And the article was included in Journal of the American Chemical Society in 2020.Related Products of 50592-87-5 This article mentions the following:
Here we describe an asym. [3,3]-sigmatropic rearrangement of aryl iodanes that enables the enantioselective α-arylation of chiral 2-oxazolines, thereby producing valuable chiral α-aryl carbonyl compounds The success of this protocol hinges on the selective assembly of aryl iodanes with 2-oxazolines and the smooth deprotonation of the in situ-generated iodonium-imine species. The nearly neutral and mild conditions of the reaction allow it to tolerate a wide variety of functional groups. Moreover, the remaining iodine atom in the products not only provides a versatile platform for further elaboration of such mols. but also supplies the asym. hypervalent iodine chem. with a new class of chiral scaffolds. Thus, e.g., for achiral case, reaction of PhI(OAc)2 with 2-pentyl-2-oxazoline in presence of 2-methylpyridine as base and TMSOTf afforded I (62%). In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Related Products of 50592-87-5).
1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 50592-87-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary