Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis was written by Takahashi, Rina;Hu, Anqi;Gao, Pan;Gao, Yunpeng;Pang, Yadong;Seo, Tamae;Jiang, Julong;Maeda, Satoshi;Takaya, Hikaru;Kubota, Koji;Ito, Hajime. And the article was included in Nature Communications in 2021.Application In Synthesis of 4-Bromo-4′-tert-butylbiphenyl This article mentions the following:
Since the discovery of Grignard reagents in 1900, the nucleophilic addition of magnesium-based carbon nucleophiles to various electrophiles has become one of the most powerful, versatile, and well-established methods for the formation of carbon-carbon bonds in organic synthesis. Grignard reagents are typically prepared via reactions between organic halides and magnesium metal in a solvent. However, this method usually requires the use of dry organic solvents, long reaction times, strict control of the reaction temperature, and inert-gas-line techniques. Despite the utility of Grignard reagents, these requirements still represent major drawbacks from both an environmental and an economic perspective, and often cause reproducibility problems. Herein, the general mechanochem. synthesis of magnesium-based carbon nucleophiles (Grignard reagents in paste form) in air using a ball milling technique is reported. These nucleophiles can be used directly for one-pot nucleophilic addition reactions with various electrophiles and nickel-catalyzed cross-coupling reactions under solvent-free conditions. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Application In Synthesis of 4-Bromo-4′-tert-butylbiphenyl).
4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application In Synthesis of 4-Bromo-4′-tert-butylbiphenyl
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary