New ianthelliformisamine derivatives as antibiotic enhancers against resistant gram-negative bacteria was written by Pieri, Cyril;Borselli, Diane;Di Giorgio, Carole;De Meo, Michel;Bolla, Jean-Michel;Vidal, Nicolas;Combes, Sebastien;Brunel, Jean Michel. And the article was included in Journal of Medicinal Chemistry in 2014.Application In Synthesis of 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:
A series consisting of ianthelliformisamimes A, B, and C as well as its synthetic analogs was prepared in high chem. yield, from 27 to 91%, using peptide coupling as the key step, and the compounds were evaluated for their in vitro antibiotic enhancer properties against resistant Gram-neg. bacteria and clin. isolates. The mechanism of action of one of these derivatives against Pseudomonas aeruginosa when combined with doxycycline was precisely evaluated utilizing bioluminescence to measure ATP efflux and fluorescence to evaluate membrane depolarization. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Application In Synthesis of 3,5-Dibromo-4-methoxybenzaldehyde).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application In Synthesis of 3,5-Dibromo-4-methoxybenzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary