1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) was written by Heerding, D. A.;Chan, G.;DeWolf, W. E.;Fosberry, A. P.;Janson, C. A.;Jaworski, D. D.;McManus, E.;Miller, W. H.;Moore, T. D.;Payne, D. J.;Qiu, X.;Rittenhouse, S. F.;Slater-Radosti, C.;Smith, W.;Takata, D. T.;Vaidya, K. S.;Yuan, C. C. K.;Huffman, W. F.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.SDS of cas: 6515-58-8 This article mentions the following:
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) were identified. Example compounds thus prepared included 4-(4-methoxyphenyl)-2-[(4-methylphenyl)methyl]-1H-imidazole, 4-(4-methoxyphenyl)-1-[(4-methylphenyl)methyl]-1H-imidazole, 1-[(4-nitrophenyl)methyl]-4-(3-thienyl)-1H-imidazole, 3-[(4-Methylphenyl)methyl]-5-(3-thienyl)-1,2,4-Oxadiazole and 4-[(4-methylphenyl)methyl]-2-(3-thienyl)oxazole. Crystal structure data showed 1-[(4-methylphenyl)methyl]-4-(2-thienyl)-1H-imidazole (inhibitor) bound in the enzyme active site of E. coli FabI. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8SDS of cas: 6515-58-8).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.SDS of cas: 6515-58-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary