The effect of bromide ions on the reaction of alkylaromatic compounds with cerium(IV) ammonium nitrate in acetic acid. An efficient method for the side-chain bromination of toluenes with electron-withdrawing substituents was written by Baciocchi, Enrico;Rol, Cesare;Sebastiani, Giovanni V.;Serena, Bernardino. And the article was included in Journal of Chemical Research, Synopses in 1984.Application of 6515-58-8 This article mentions the following:
Treatment of RR1C6H3Me [R = 3-CO2H, 4-NO2, 4-(2-HO2C)C6H4CO, 4-Br, H, R1 = H; R = 2-Cl, R1 = 4-Cl, 6-Cl] with (NH4)2Ce(NO3)6 in AcOH-KBr at 80° for 1-2.5 h gave RR1C6H3CH2Br (I) in 50-80% yield. As I can be converted into RR1C6H3CH2OAc in the same reaction medium, this provides a method for side-chain acetoxylation of toluenes. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Application of 6515-58-8).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 6515-58-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary