Month: December 2022

Patterson, Steven published the artcileFluorescence sensing of a ribonucleoside 5′-triphosphate, Product Details of C12H16BBrO2, the publication is Tetrahedron Letters (1997), 38(36), 6323-6326, database is CAplus.

Conjugation of a fluorescent saccharide sensor to poly(allylamine) produces a sensing compound with selectivity for ribonucleoside 5′-triphosphate. An association constant (log K_a) of 5.6 was determined for UTP in pH 7.3 phosphate solution (15 mM, 298 K), whereas log K_a was less than 2 for uridine, UMP, and UDP.

Tetrahedron Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Product Details of C12H16BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kay, A. W. published the artcileThe action of atropine and hexamethonium in combination on gastric secretion and motility, Related Products of bromides-buliding-blocks, the publication is British Journal of Pharmacology and Chemotherapy (1956), 231-5, database is CAplus and MEDLINE.

Hexamethonium or atropine administered singly had less effect on human gastric secretion and motility than their combination in half the single dose. Such combinations produced fewer side effects than either drug alone.

British Journal of Pharmacology and Chemotherapy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Piou, Tiffany published the artcileDirect Arylation of Azoles Enabled by Pd/Cu Dual Catalysis, SDS of cas: 25753-84-8, the publication is Organic Letters (2021), 23(6), 1996-2001, database is CAplus and MEDLINE.

A practical approach toward the synthesis of 2-arylazoles via direct arylation was described. The transformation relied on a Pd/Cu cocatalyst system that operated with low catalyst loadings. The reaction conditions were found to be tolerant of a wide range of functional groups and nitrogen-containing heterocycles commonly employed in a drug discovery setting.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, SDS of cas: 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wibaut, J. P. published the artcileEffect of temperatures and catalysts on the bromination of naphthalene; the α-bromonaphthalene ⇄ β-bromonaphthalene equilibrium, Quality Control of 52358-73-3, the publication is Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen (1948), 776-86, database is CAplus.

The content of β-monobromonaphthalene increases slowly with temperature of reaction over the range 85° to 215° according to ln(Cα/Cβ) = (Εβ – Εα)/RT where Ε is the energy of activation of the bromination reaction. Εβ – Εα = 2498 cal./mol. in agreement with exptl. results of Suyver and Wibaut. (C.A. 40, 3428). Catalysts (FeCl₃ or FeBr₃) cause an increase in amount of β-mono-, di-, and tribrominated products. Uncatalyzed: about 3-8% β in a yield of 50-60% C₁₀H₇Br over the range 85-215° is obtained; catalyzed: about 22 to 48% β in a yield of 37-42% C₁₀H₇Br. The yield is affected greatly by reaction time, etc. Either α- or β-C₁₀H₇Br in contact with FeCl₃ or FeBr₃ at 150° gives the same equilibrium mixture of 40% α and 60% β. No such conversion occurs in the absence of catalyst. Equilibrium mixtures contain 63.1% β at 100°, 62.3% β at 150°, 60.4% β at 200°, and 58.8% β at 250°. ΔH conversion α ⇄ β is calculated as -500 ± 130 cal./mol. 1,2-, 1,3-, and 1,6-Dibromonaphthalene +HBr + FeCl₃ at 150° → 56% β- and 44% α-C₁₀H₇Br + Br₂. An ionic mechanism is proposed, although wave-mech. calculations are discussed which support either ionic or free-radical mechanisms. Catalyzed vapor-phase bromination of C₁₀H₈ yields 55.35% (calculated on Br) C₁₀H₇Br in range 250°. The kinetics and mechanism of this reaction are discussed. Again either α- or β-C₁₀H₇Br passed over a catalyst in gas phase yields an equilibrium mixture of about 60% β and 40% α.

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C4H10O2, Quality Control of 52358-73-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Koelle, U. published the artcileCpCoBr intermediates in the cyclopentadienylation of CoBr₂ with sodium cyclopentadienide, Computed Properties of 18346-57-1, the publication is Journal of Organometallic Chemistry (1982), 233(2), 253-8, database is CAplus.

Reaction of CoBr₂ and NaCp (Cp = η⁵-cyclopentadienyl) at low temperature, followed by addition of diene or acetylene gives the complexes CpCo(diene). The scope and mechanism of this novel reaction were investigated. The intermediate is [CpCoBr]₂. Further reaction of Cp₂Co and CoBr₂ gives [CoCp₂]Br and Co, the amounts of which vary with the reaction time.

Journal of Organometallic Chemistry published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Computed Properties of 18346-57-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Giribabu, L. published the artcileHighly Efficient Sulfimidation of 1,3-Dithianes by Cu(I) Complexes, Safety of Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is Synthetic Communications (2008), 38(4), 619-625, database is CAplus.

Four Cu(I) complexes were tested for sulfimidation of 1,3-dithianes in the presence of [N-(p-tolysulfonyl)imino]phenyliodinane (PhI:NTs) as the nitrene-transfer agent. Newly prepared Cu(TMPhen)(PPh₃)Br (TMPhen = 3,4,7,8-tetramethyl-1,10-phenanthroline) is an efficient catalyst with >90% yield of the corresponding product with less reaction time as compared to Cu(PPh₃)₃Br (1) Cu(Phen)(PPh₃)Br (2), and Cu(neocuproin)(PPh₃)Br (3).

Synthetic Communications published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Safety of Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Xin published the artcileInfluence of polybenzimidazole main chain structure on H₂/CO₂ separation at elevated temperatures, COA of Formula: C7H8BrClFN, the publication is Journal of Membrane Science (2014), 59-68, database is CAplus.

Four polybenzimidazole (PBI) derivatives were prepared to study the effects of main chain chem. and structure on H₂/CO₂ perm-selectivity of cast films. These structural variations were designed to exhibit high localized mobility at elevated temperatures, contain rigid and bent configurations that frustrated close chain packing, or possess bulky side groups. The modified PBIs exhibited high mol. weights, slightly lower thermal stabilities, and higher organo-solubilities compared with com. m-PBI. Dilute polymer solutions (<3.0 wt%) were used to fabricate high quality thin films under carefully optimized film processing conditions. Gas permeation properties of these PBI films were evaluated at elevated temperatures (up to 250 °C) and pressures (up to 50 psia). The main chain structural variations effectively disrupted the PBI chain packing resulting in much improved film H₂ permeability (up to 997.2 barrer) compared with m-PBI (76.81 barrer) at 250 °C and 50 psia. However, lower H₂/CO₂ selectivities (5-7 (modified PBIs) vs. 23 (m-PBI)) were also measured and reflected the general trade-off between gas permeability and selectivity. When tested at 250 °C, PBI-based materials exhibited gas separation performance higher than the Robeson upper bound prediction and are promising materials for high temperature H₂ separation from syngas.

Journal of Membrane Science published new progress about 147181-08-6. 147181-08-6 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Salt,Amine,Benzene, name is (4-Bromo-2-fluorophenyl)methanamine hydrochloride, and the molecular formula is C7H8BrClFN, COA of Formula: C7H8BrClFN.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Barnych, Bogdan published the artcileDevelopment of potent inhibitors of the human microsomal epoxide hydrolase, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2020), 112206, database is CAplus and MEDLINE.

Microsomal epoxide hydrolase (mEH) hydrolyzes a wide range of epoxide containing mols. Although involved in the metabolism of xenobiotics, recent studies associate mEH with the onset and development of certain disease conditions. This phenomenon is partially attributed to the significant role mEH plays in hydrolyzing endogenous lipid mediators, suggesting more complex and extensive physiol. functions. In order to obtain pharmacol. tools to further study the biol. and therapeutic potential of this enzyme target, we describe the development of highly potent 2-alkylthio acetamide inhibitors of the human mEH with IC₅₀ values in the low nanomolar range. These are around 2 orders of magnitude more potent than previously obtained primary amine, amide and urea-based mEH inhibitors. Exptl. assay results and rationalization of binding through docking calculations of inhibitors to a mEH homol. model indicate that an amide connected to an alkyl side chain and a benzyl-thio function as key pharmacophore units.

European Journal of Medicinal Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mayer, Anna published the artcileGas chromatographic method for the determination of isomeric bromoisobutyric acids and their chlorides, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Analyst (Cambridge, United Kingdom) (1987), 112(5), 657-9, database is CAplus.

A gas chromatog. method for the determination of 3-bromoisobutyric acid and the isomeric 2-bromoisobutyric acid, 2,3-dibromoisobutyric acid and methacrylic acid as their trimethylsilyl esters was developed. The determination of the corresponding acid chlorides was performed after their conversion to the corresponding morpholides.

Analyst (Cambridge, United Kingdom) published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Amsharov, K. Yu. published the artcileFormation of fullerenes by pyrolysis of 1,2′-binaphthyl and 1,3-oligonaphthylene, HPLC of Formula: 52358-73-3, the publication is Carbon (2007), 45(2), 337-343, database is CAplus.

High-temperature pyrolysis of two fullerene precursors, 1,2′-binaphthyl and 1,3-oligonaphthyl, has been investigated. An oligomer of naphthalene with the appropriate orientation of fragments, which contains all 60 carbon atoms, 12 of 20 six-membered rings and 71 of 90 carbon-carbon bonds required to form the C₆₀ fullerene cage was synthesized in a three-step synthesis from naphthalene. The formation of fullerene during pyrolysis was confirmed by MALDI-TOF and HPLC anal. of the toluene extract obtained from the raw soot. It was found that the toluene extract contains free C₆₀ fullerene but the main share of fullerenes exists in the form of their derivatives The yield of free C₆₀ was estimated as 0.1% by HPLC but the overall yield of C₆₀ seems to be higher and was estimated as ≈1%.

Carbon published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, HPLC of Formula: 52358-73-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary