Synthesis of N-alkoxyindol-2-ones by copper-catalyzed intramolecular N-arylation of hydroxamates was written by Kukosha, Tatyana;Trufilkina, Nadezhda;Katkevics, Martins. And the article was included in Synlett in 2011.Synthetic Route of C7H5Br2F This article mentions the following:
The first example of copper-catalyzed intramol. N-arylation of hydroxamic acid derivatives is presented. Based on this transformation a new method for the synthesis of N-alkoxyindol-2-ones from 2-(2-bromoaryl)acetylhydroxamates has been developed. E.g., CuBr2 catalyzed the intramol. N-arylation of hydroxamate (I) to give 91% N-methoxyindol-2-one (II). The reaction conditions tolerate standard hydroxyl protecting groups on the hydroxylamine moiety and are also applicable for the synthesis of six-membered N-alkoxybenzolactams. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Synthetic Route of C7H5Br2F).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C7H5Br2F
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary