Zhu, Shaojuan published the artcileIn vitro and in vivo evaluation of antioxidant activity of ARIs: benzothiadiazine and pyridothiadiazine derivatives, Application of 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Journal of Chemical and Pharmaceutical Research (2014), 6(5), 173-179, 7 pp., database is CAplus.
Increased oxidant stress plays an important role in the chronic complications of diabetes. This study aimed to examine if our previously synthesized aldose reductase inhibitors (ARIs), benzothiadiazine 1,1-dioxide derivatives and the structural analogs pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide derivatives, have the potent as antioxidants. Several assays have been used to estimate antioxidant capacities including DPPH, MDA and sorbitol assays. Effect of concentration, PH and sunlight on DPPH scavenging activity were determined, and results showed benzothiadiazine 1,1-dioxide derivatives (compound 7a, 7b, 7c) at both concentration of 10-5 M and 10-4 M had notable scavenging activity against DPPH, significantly higher than that of pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide derivatives(compound 7’a, 7’b, 7’c). The PH demonstrated no effect on the activity and sunlight was essential for the activity. The brain MDA levels (MDA, an index of lipid peroxidation) for compounds 7a, 7b, 7c significantly decreased comparing with the neg. control, the brain homogenate sample induced by oxidant system Fe(III) ascorbic acid. Oral administration of compound 7’a, 7’b and 7’c to groups of STZ-induced rats for 5 days decreased the level of sciatic nerve sorbitol, The inhibition of sorbitol level in the range of 24%-35% for 7’a, 7’b and 7’c, showing some difference with the in vitro study.
Journal of Chemical and Pharmaceutical Research published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C18H20N2O12, Application of 4-Bromo-1-(bromomethyl)-2-fluorobenzene.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary