Zhao, Zhen-Zhen published the artcileNickel-Catalyzed Reductive C(sp2)-Si Coupling of Chlorohydrosilanes via Si-Cl Cleavage, Application In Synthesis of 111-83-1, the publication is Angewandte Chemie, International Edition (2022), 61(21), e202200215, database is CAplus and MEDLINE.
Authors report here a new method for the synthesis of organohydrosilanes from phenols and ketones. This method is established through reductive C-Si coupling of chlorohydrosilanes via unconventional Si-Cl cleavage. The reaction offers access to aryl- and alkenylhydrosilanes with a scope that is complementary to those of the established methods. Electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles, as well as cyclic and acyclic alkenyl electrophiles, were coupled successfully. Functionalities, including Grignard-sensitive groups (e.g., primary amine, amide, phenol, ketone, ester, and free indole), acid-sensitive groups (e.g., ketal and THP protection), alkyl-Cl, pyridine, furan, thiophene, Ar-Bpin, and Ar-SiMe3, were tolerated. Gram-scale(coating) reaction, incorporation of -Si(H)R2 into complex biol. active mols., and derivatization of formed organohydrosilanes are demonstrated.
Angewandte Chemie, International Edition published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C5H13Cl2N, Application In Synthesis of 111-83-1.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary