Thangarasu, Arun K. published the artcileDesign, synthesis, and preliminary immunopotentiating activity of new analogues of nojirimycin, Computed Properties of 111-83-1, the publication is Carbohydrate Research (2022), 108479, database is CAplus and MEDLINE.
Three new classes of nojirimycin analogs viz. N-alkyl with C1-substituent (4-phenylbutyl), N-substituted 1-deoxynojirimycin and its congener Δ-lactam, and a 4-phenylbutyl-β-C-glycoside were designed and synthesized for immunol. studies. The resulting diverse compound library exhibited proliferation of B Cells and T cells induced by LPS and Con A, resp. The majority of the analogs augmented the secretion of IL-12 in dendritic cells and TNF-α secretion in murine peritoneal macrophages compared to LPS (10μg/mL). A deoxynojirimycin-triazole conjugate of phytosphingosine analog was superior in the responses mentioned above and exhibited nitric oxide response equal to LPS. In comparison to findings on its congeners with immunosuppressive action, early immunol. tests show that the novel nojirimycin analogs have immunopotentiating effect. Nojirimycin analogs offer tremendous potential in tuning the immunomodulatory activity of iminosugars by subtle to substantial structural variations.
Carbohydrate Research published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C20H12N2O2, Computed Properties of 111-83-1.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary