Ramu, Avner published the artcileReduced ouabain-sensitive potassium entry as a possible mechanism of multidrug-resistance in P388 cells, Application of Dimidium bromide, the publication is Biochemical Pharmacology (1991), 42(9), 1699-704, database is CAplus and MEDLINE.
Multidrug-resistant P388 cells were found to be resistant also to a variety of ammonium, phosphonium and arsonium compounds As previously shown for anthracyclines and vinca alkaloids, the resistance to the permanently charged lipophilic cationic compounds could be circumvented by verapamil. Relative to drug-sensitive cells, K+ uptake and plasma membrane Mg-ATPase activity in multidrug-resistant cells are ouabain resistant. The intracellular K+ concentration in drug-resistant cells is maintained at a normal level by increased activity of the furosemide sensitive transport system. It is suggested that the reduced activity of the electrogenic Na+-K+ pump in multidrug-resistant cells could result in a lower transmembrane potential and therefore reduced accumulation of cationic lipophilic compounds
Biochemical Pharmacology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Application of Dimidium bromide.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary