Iyer, Malliga R. published the artcileProbes for narcotic receptor mediated phenomena. 47.1 Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols, Safety of 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, the publication is Bioorganic & Medicinal Chemistry (2013), 21(11), 3298-3309, database is CAplus and MEDLINE.
A series of N-Me rac-cis-4a-aralkyl- and alkyl-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols have been prepared using a simple previously designed synthetic route, to find a ligand that would interact with both μ- and δ-opioid receptors. A C4a-phenethyl derivative I, was found to have modest receptor affinity both at μ- (Ki = 60 nM) and δ-opioid receptors (Ki = 64 nM). The N-Me substituent of I and that of other ligands in the series was then modified to obtain compounds with different N-substituents that might provide higher affinity at both receptors. A number of compounds differently substituted at C4a and N were synthesized and evaluated. Binding studies and functional assays revealed a moderately selective δ-antagonist, selective μ-δ antagonists, and a μ-κ antagonist.
Bioorganic & Medicinal Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Safety of 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary