Harwood, Stephen J. published the artcileModular terpene synthesis enabled by mild electrochemical couplings, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Science (Washington, DC, United States) (2022), 375(6582), 745-752, database is CAplus and MEDLINE.
The synthesis of terpenes is a large field of research that is woven deeply into the history of chem. Terpene biosynthesis is a case study of how the logic of a modular design can lead to diverse structures with unparalleled efficiency. This work leverages modern nickel-catalyzed electrochem. sp2-sp3 decarboxylative coupling reactions, enabled by silver nanoparticle-modified electrodes, to intuitively assemble terpene natural products and complex polyenes by using simple modular building blocks. The step change in efficiency of this approach is exemplified through the scalable preparation of 13 complex terpenes, which minimized protecting group manipulations, functional group interconversions, and redox fluctuations. The mechanistic aspects of the essential functionalized electrodes are studied in depth through a variety of spectroscopic and anal. techniques. Safety: numerous safety warnings are provided, including hazards associated with RVC dust and pyrophoric Pd/C catalysts.
Science (Washington, DC, United States) published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary