Gunsalus, Robert P. published the artcilePreparation of coenzyme M analogs and their activity in the methyl coenzyme M reductase system of Methanobacterium thermoautotrophicum, Category: bromides-buliding-blocks, the publication is Biochemistry (1978), 17(12), 2374-7, database is CAplus and MEDLINE.
A number of 2-(methylthio)ethanesulfonate (Me-coenzyme M, I) analogs were synthesized and investigated as substrates for I reductase, an enzyme system found in extracts of M. thermoautotrophicum. Replacement of the Me moiety by an Et group yielded an analog which served as a precursor for C2H6 formation. Pr-coenzyme M, however, was not converted to C3H8. Analogs which contained addnl. methylene C atoms, such as 3-(methylthio)propanesulfonate or 4-(methylthio)butanesulfonate or analogs modified at the sulfide or sulfonate position, N-methyltaurine and 2-(methylthio)ethanol, were inactive. These analogs, in addition to a number of com. available compounds, also were tested for their ability to inhibit the reduction of I to CH4. Bromoethanesulfonate and chloroethanesulonate proved to be potent inhibitors of the reductase, resulting in 50% inhibition at 7.9 × 10-6 M and 7.5 × 10-5 M, resp. Analogs of coenzyme M which contained modifications to other regions were also evaluated and found to be weak inhibitors of CH4 biosynthesis.
Biochemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Category: bromides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary