Doebelin, Christelle published the artcileIdentification of potent RORβ modulators: Scaffold variation, Name: (3-Bromo-5-isopropoxyphenyl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(19), 3210-3215, database is CAplus and MEDLINE.
The authors sought to develop RORβ-selective probe mols. to investigate the function of the receptor in vitro and in vivo and its role in the pathophysiol. of disease. To accomplish this, the authors modified a potent dual RORβ/RORγ inverse agonist from the primary literature with the goal of improving selectivity for RORβ vs. RORγ. Truncation of the Western portion of the mol. ablated activity at RORγ and led to a potent series of RORβ modulators. Continued exploration of this series investigated alternate replacement cores for the aminothiazole ring. Numerous suitable replacements were found during the course of the authors’ SAR investigations and are reported herein.
Bioorganic & Medicinal Chemistry Letters published new progress about 871125-81-4. 871125-81-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Bromo-5-isopropoxyphenyl)boronic acid, and the molecular formula is C9H12BBrO3, Name: (3-Bromo-5-isopropoxyphenyl)boronic acid.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary