Arora, Vinod K. published the artcileA novel ring oxidation of 4- or 5-substituted 2H-oxazole to corresponding 2-oxazolone catalyzed by cytosolic aldehyde oxidase, COA of Formula: C9H6BrNO, the publication is Drug Metabolism & Disposition (2012), 40(9), 1668-1676, database is CAplus and MEDLINE.
The ring oxidation of 2H-oxazole, or C2-unsubstituted oxazole, to 2-oxazolone, a cyclic carbamate, was observed on various 4- or 5-substituted oxazoles. Using 5-(3-bromophenyl)oxazole as a model compound, its 2-oxazolone metabolite M1 was fully characterized by liquid chromatog./tandem mass spectrometry and NMR. The reaction mainly occurred in the liver cytosolic fraction without the requirement of cytochrome P 450 enzymes and cofactor NADPH. Investigations into the mechanism of formation of 2-oxazolone using various chem. inhibitors indicated that the reaction was primarily catalyzed by aldehyde oxidase and not by xanthine oxidase. In addition, cytosol incubation of 5-(3-bromophenyl)oxazole in the medium containing H218O led to the 18O incorporation into M1, substantiating the reaction mechanism of a typical molybdenum hydroxylase. The rank order of liver cytosols for the 2-oxazolone formation was mouse > monkey >> rat and human liver cytosol, whereas M1 was not formed in dog liver cytosol. Because the reaction was observed with a number of 4- or 5-substituted 2H-oxazoles in mouse liver cytosols, 2H-oxazoles represent a new substrate chemotype for ring oxidation catalyzed by aldehyde oxidase.
Drug Metabolism & Disposition published new progress about 243455-57-4. 243455-57-4 belongs to bromides-buliding-blocks, auxiliary class Oxazole,Bromide,Benzene, name is 5-(3-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, COA of Formula: C9H6BrNO.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary