Wu, Bobin published the artcileSynthesis and Structure-Activity Relationship Studies of Quinoxaline Derivatives as Aldose Reductase Inhibitors, COA of Formula: C7H5Br2F, the publication is ChemMedChem (2013), 8(12), 1913-1917, database is CAplus and MEDLINE.
Neuropathy, nephropathy, retinopathy, and cataracts are common complications in people with chronic diabetes caused by insulin deficiency or insulin resistance. Previous studies have suggested that the polyol pathway becomes activated under hyperglycemic conditions, leading to accumulation of sorbitol and then to diabetic complications. Aldose reductase 2 inhibition could be a key to decreasing the accumulation of sorbitol. Aldose reductase inhibitors have attracted great attention for their potential to treat diabetic complications. This study focuses on new series of quinoxaline derivatives, their synthesis, Aldose reductase 2 inhibition and structure-activity relationships.
ChemMedChem published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H13NO2, COA of Formula: C7H5Br2F.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary