Wien, R. published the artcileChemotherapeutic action of amidine and phenanthridinium compounds in Trypanosoma congolense infections, SDS of cas: 518-67-2, the publication is British Journal of Pharmacology and Chemotherapy (1946), 65-80, database is CAplus and MEDLINE.
These compounds were tested against 5 strains of T. congolense in mice: 7-Amino-9-p-aminophenyl-10-methylphenanthridinium chloride and 4,4′-diamidino-α,β-dimethylstilbene di-HCl were compared as to activity. The former compound was twice as toxic and active against the acute strains, the therapeutic indexes being the same, but it was less active against 1 chronic strain. An evaluation of 2,7-diamino-9-phenyl-10-methyl-phenanthridinium bromide (1553) showed that by subcutaneous injection in acute infections the C.D. 50(50% of animals free of trypanosomes for at least 28 days, 42 for chronic strains) was 0.0004 mg./g., the LD 50 was 0.061 mg./g. and the therapeutic index 152. A very complete study of the correlation between chem. structure and activity against T. congolense of diamidine and phenanthridinium compounds is reported. The pharmacol. actions of compound 1553 are reported. The compound has a depressant action on the circulation and respiratory center and, in high doses, a toxic action on liver and kidneys.
British Journal of Pharmacology and Chemotherapy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C17H14F3N3O2S, SDS of cas: 518-67-2.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary