Tsuji, Hayato published the artcileIndium-catalyzed cycloisomerization of ψ-Alkynyl-β-keto esters into six- to fifteen-membered rings, Application In Synthesis of 81216-14-0, the publication is Angewandte Chemie, International Edition (2007), 46(42), 8060-8062, database is CAplus and MEDLINE.
Many different sizes of rings are made available via heating of ψ-alkynyl-β-keto esters in the presence of In(NTf2)3 (Tf = trifluoromethanesulfonyl). The products, produces six- to fifteen-membered ring compounds are produced in good yields. The reaction features low catalyst loading and moderately dilute conditions, and the formation of medium-sized rings is sometimes faster than that for the corresponding six-membered rings. Cycloisomerization of 3-oxo-16-heptadecynoic acid Me ester gave 2-methyl-15-oxo-1-cyclopentadecene-1-carboxylic acid Me ester. Reduction of the latter gave 2-methyl-15-oxo-1-cyclopentadecanecarboxylic acid Me ester. Decarboxylation of this intermediate gave (±)-muscone (i.e., 3-methylcyclopentadecanone).
Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C18H10F3NO3S2, Application In Synthesis of 81216-14-0.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary