Liu, Shunjie published the artcileMolecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics, HPLC of Formula: 303734-52-3, the publication is Journal of the American Chemical Society (2019), 141(13), 5359-5368, database is CAplus and MEDLINE.
Planar donor and acceptor (D-A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order to restrict intramol. motions in aggregates (nanoparticles). However, other channels of extra nonradiative decay may be blocked. Now this challenge is addressed by proposing an “abnormal” strategy based on mol. motion in aggregates. Mol. rotors and bulky alkyl chains are grafted to the central D-A core to lower intermol. interaction. The enhanced mol. motion favors the formation of a dark twisted intramol. charge transfer state, whose nonradiative decay enhances the photothermal properties. Result shows that small-mol. NIRb14 with long alkyl chains branched at the second carbon exhibits enhanced photothermal properties compared with NIRb6, with short branched chains, and much higher than NIR6, with short linear chains, and the com. gold nanorods. Both in vitro and in vivo experiments demonstrate that NIRb14 nanoparticles can be used as nanoagents for photoacoustic imaging-guided photothermal therapy. Moreover, charge reversal poly(β-amino ester) makes NIRb14 specifically accumulate at tumor sites. This study thus provides an excited mol. motion approach toward efficient phototheranostic agents.
Journal of the American Chemical Society published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, HPLC of Formula: 303734-52-3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary