Li, Chengwen published the artcileSynthesis of difluoroalkylated 2-azaspiro[4.5]decane derivatives via copper-catalyzed difluoroalkylation/dearomatization of N-benzylacrylamides, Related Products of bromides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2020), 18(41), 8376-8380, database is CAplus and MEDLINE.
An efficient method for the synthesis of difluoroalkylated 2-azaspiro[4.5]decanes I [R1 = H, 7-OMe, 7-F, etc.; R2 = iPr, tBu, adamantan-1-yl; R3 = H, Me; R4 = EtO2C, Et2NCO, 1-pyrrolidinylcarbonyl, 1-piperidinylcarbonyl, 2,3-dihydro-1-indolylcarbonyl] via copper-catalyzed difluoroalkylation of N-benzylacrylamides with halo- fluoroacetate/difluoroacetate was established. The reaction experienced a tandem radical addition and dearomatizing cyclization process. In addition, the resultant products could be smoothly converted into a difluoroalkylated quinolinone and saturated spirocyclohexanone scaffold.
Organic & Biomolecular Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Related Products of bromides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary