Lerman, L. S. published the artcileSymposium on molecular action of mutagenic and carcinogenic agents. Acridine mutagens and DNA structure, Recommanded Product: Dimidium bromide, the publication is Journal of Cellular and Comparative Physiology (1964), 64(2;Pt. II;Suppl. 1), 1-13, discussion 13-18, database is CAplus.
Evidence for intercalation of acridine compounds between 2 otherwise sequential base pairs was obtained by studies of sedimentation, low angle x-ray scattering, flow dichroism, flow-polarized fluorescence, and chem. reactivity. Such binding requires a local untwisting and extension of the double helix. The intercalated mols. have a decreased chem. reactivity. They increase the stability of the double helix as shown by an increase in the thermal transition temperature Intercalation into complexes formed between polyadenylic and polyuridylic acids makes the double helix more stable than the triple. Intercalation seems to be a prerequisite for mutagenicity of the insertion-deletion type but the acridine structure is not essential and not all intercalating mols. are mutagenic.
Journal of Cellular and Comparative Physiology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary