Larsson, Erik’s team published research in Chalmers Tekniska Hoegskolas Handlingar in No. 35 | CAS: 56970-78-6

Chalmers Tekniska Hoegskolas Handlingar published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Name: 3-Bromo-2-methylpropanoic acid.

Larsson, Erik published the artcileSome S-containing β-substituted derivatives of isobutyric acid, Name: 3-Bromo-2-methylpropanoic acid, the publication is Chalmers Tekniska Hoegskolas Handlingar (1944), 3-17, database is CAplus.

The preparation is described of β-alkyl, β-aryl, and β-arylalkyl sulfide derivatives, RSCH2CHMeCO2H (I), and of the corresponding sulfone carboxylic acids, RSO2CH2CHMeCO2H (II). The synthesis of BrCH2CHMeCO2H (III) was improved by interacting HBr with CH2: CMeCO2H (IV) in CHCl3. HSCH2CHMeCO2H (V) was prepared from (1) IV via MeCOSCH2CHMeCO2H, (2) III and NaHS, or (3) fission of EtOCS2CH2CHMeCO2H prepared from EtOCS2K and III. The Me derivative of V was prepared in aqueous solution by reaction of the di-Na salt of V with Me2SO4 or KMeSO4; the Et, Pr, PhCH2, and PhCH2CH2 derivatives from their halides and the di-Na salt of V in aqueous alc. solution The Ph derivative was prepared in aqueous solution from PhSNa and the Na salt of III. All of the sulfide acids (I) prepared consumed 4 equivalents of Br per mol. on oxidation in HCl solution, indicating conversion to the sulfone carboxylic acids (II). The latter were prepared by Br or KMnO4 oxidation. The following phys. properties are given for I (R given): b.p./mm., d420, nD20, nF20-nC20, MRD(found) and mol. volume at 20°: Me 129-30°/12, 1.1086, 1.4815, 0.0112, 34.48, 121.1; Et 140-1°/12, 1.0684, 1.4780, 0.0110, 39.27, 138.7; Pr 138-9°/6, 1.0405, 1.4761, 0.0107, 43.97, 155.9; and PhCH2CH2 190-5°/6, 1.1207, 1.5450, 0.0159, 63.28, 200.1. The I where R is iso-Pr b8 135-7°, m. 31°; Ph m. 45°; PhCH2 m. 43°. The m.ps. of the following II are: Me 134°, Et 82°, Pr 75-6°, iso-Pr 109°, Ph 113°, PhCH2 154°, and PhCH2CH2 93°. The PhCH2 derivative of V was oxidized by K2S2O8 or H2O2 to the sulfoxide (m. 110-11°) but the 2 theoretically possible forms of PhCH2SOCH2CHMeCO2H could not be isolated. Oxidation of V with Br gave the sulfone acid. Compounds like II apparently ionize thus in alk. solution: RSO2CH2CHMeCO2– + OH– = RSO2– + CH2:CMe-CO2– + H2O.

Chalmers Tekniska Hoegskolas Handlingar published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Name: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary