Kounde, Cyrille S. published the artcileDiscovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit, Synthetic Route of 56970-78-6, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(6), 1385-1389, database is CAplus and MEDLINE.
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 (I) as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the identification of compound (S)-29, which exhibited potent anti-dengue activity in the cell-based assay across all four dengue serotypes with EC50 < 0.1 μM. Cross-resistant anal. confirmed that the virus NS4B protein remained the target of the new oxopiperazine analogs obtained via scaffold morphing from the HTS hit 4.
Bioorganic & Medicinal Chemistry Letters published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Synthetic Route of 56970-78-6.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary