Gerken, Philip A. published the artcileDiscovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7, Application In Synthesis of 81216-14-0, the publication is Angewandte Chemie, International Edition (2017), 56(49), 15555-15559, database is CAplus and MEDLINE.
Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation of gene expression, yet there are few selective, cell-permeable inhibitors or suitable tool compounds for these enzymes. The authors describe the discovery of a new class of inhibitor that is highly potent towards the histone lysine demethylases KDM2A/7A. A modular synthetic approach was used to explore the chem. space and accelerate the investigation of key structure-activity relationships, leading to the development of a small mol. with around 75-fold selectivity towards KDM2A/7A vs. other KDMs, as well as cellular activity at low micromolar concentrations
Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Application In Synthesis of 81216-14-0.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary