Buschmann, N. published the artcileIndicator for the two-phase titration of ionic surfactants is possibly mutagenic, Product Details of C20H18BrN3, the publication is Rivista Italiana delle Sostanze Grasse (1995), 72(11), 513, database is CAplus.
For the two-phase titration of anionic or cationic surfactants, the most frequently used indicator is a mixed indicator system consisting of dimidium bromide and Disulphine Blue. Recently, we noticed a similarity between ethidium bromide and dimidium bromide (I). Ethidium bromide is well known as a strong mutagenic and cancerogenic agent, reacting with DNA either by intercalation or external binding. The literature shows that I reacts with DNA in a similar way. When mixing aqueous solutions of DNA and I a change in the color of the solution can be observed, as well as a strong enhancement in the fluorescence intensity. Both the literature and the exptl. findings make it very likely that I shows mutagenic and cancerogenic properties that are similar to those of ethidium bromide. This estimation is shared by the USA National Cancer Institute. Up to now, only little is known about the ways of incorporation for both dyes. Ethidium bromide shows mutagenic and cancerogenic properties when coming in contact with the mucous membrane. The author has no information whether I will be incorporated if an aqueous solution is in contact with the intact epidermis. That would be the most probable way of incorporation when carrying out a two phase titration For that reason, the appropriate safety precautions should be taken when working with I: protection gloves and goggles and addnl., when working with the solid substance, dust mask. When titrating anionic surfactants, I will be found in the aqueous phase at the end of the titration The dye should be removed from the solution by adsorption on activated charcoal or on a polymeric resin like Amberlite XAD-16. After our experience an amount of 10 g activated charcoal is sufficient for the removal of I from one liter of the aqueous phase.
Rivista Italiana delle Sostanze Grasse published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Product Details of C20H18BrN3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary