Barasa, Leonard published the artcileAn Efficient Chemo-Selective N-Alkylation Methodology for the Structure Diversification of Indolylbenzimidazoles, Quality Control of 21101-63-3, the publication is ChemistrySelect (2020), 5(11), 3173-3178, database is CAplus.
A simple and efficient methodol. for the chemoselective N-alkylation of indolylbenzimidazole scaffolds was reported. This approach took advantage of the pKa differences between indole and benzimidazole nitrogen to achieve desired chemo-selectivity. Using the reported method, one could readily access a selection of mono-N-alkylated indolylbenzimidazoles I [R = Me, CH2CH=CH2, Bn, etc.; R1 = H, OMe] or asym. bis-alkylated indolylbenzimidazoles II [R2 = Me, C≡CH, cyclopropyl, Ph; R3 = Me, C≡CH, cyclopropyl] in a simple one-pot operation. Moreover, this method provided the desired products in excellent yield and demonstrated a broad substrate scope.
ChemistrySelect published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Quality Control of 21101-63-3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary